Dr. L Snyder

Senior Lecturer
Tel: +44(0)20 8417 2003
Fax: +44(0)20 8547 7562
E-mail: l.snyder@kingston.ac.uk

 

Teaching Area:
Biotechnology

Qualifications:
BS in Biology in 1993 at The College of William and Mary, Williamsburg, Virginia, USA
MA in Biology in 1995 at The College of William and Mary, Williamsburg, Virginia, USA
PhD in Microbiology and Molecular Genetics in 2001 at Emory University, Atlanta, Georgia, USA

Previous employment:
University of Birmingham, Centre for Systems Biology, Research Fellow, 2007-2008
University of Oxford, Sir William Dunn School of Pathology, Post-doctoral Scientist, 2000-2007

Research Interests:

• Bacterial comparative genomics and transcriptomics
• Bacterial horizontal gene transfer, particularly involving Minimal Mobile Elements
• Pathogenesis, genomics, and transcriptomics of Neisseria gonorrhoeae and Neisseria meningitidis

Course Responsibilities:
Course Director, MSc Biotechnology
Module Leader, LSM230 Biotechnology
Module Leader, LSM201 Medical Biotechnology
Module Leader, LSM250 Research Project

Other Professional Activities:
Editor in Chief of Sequencing
Editorial Board member of the Journal of Biomedicine and Biotechnology

Publications

The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats. PCY Woo, SKP Lau, H Tse, JLL Teng, SOT Curreem, RYY Fan, AKL Tsang, GKM Wong, Y Huang, NJ Loman, JC Cai, J-D Huang, MJ Pallen, LAS Snyder, PKH Tam, S Lok, L-C Tsui, K-Y Yuen. PLoS Genetics - in press.
http://www.plosgenetics.org

Comparative analysis of two Neisseria gonorrhoeae genome sequences reveals evidence of mobilization of Correia Repeat Enclosed Elements and their role in regulation. LAS Snyder, JACole & MJPallen. BMC Genomics 10: article 70, (2009).
http://www.biomedcentral.com/1471-2164/10/70

Uncovering the microbial unknown. LAS Snyder, NJ Loman, MJ Pallen & CW Penn. Microbial Ecology 57: 1-3, (2009).
http://www.springerlink.com/content/juj26264u71pn116/

Bacterial flagellar diversity and evolution: seek simplicity and distrust it? LAS Snyder, NJ Loman, Klaus Fütterer & MJ Pallen. Trends in Microbiology 17: 1-5, (2009).
http://www.sciencedirect.com/science/journal/0966842X

xBASE2: A comprehensive resource for comparative bacterial genomics. RR Chaudhuri, NJ Loman, LAS Snyder, CM Bailey, D Stekel & MJ Pallen. Nucleic Acids Research 36: D543-546, (2008).
http://nar.oxfordjournals.org/cgi/reprint/36/suppl_1/D543

The repertoire of Minimal Mobile Elements in the Neisseria species and evidence that these are involved in horizontal gene transfer in other bacteria. LAS Snyder, S McGowan, M Rogers, E Duro, E O'Farrell & NJ Saunders. Molecular Biology and Evolution 24: 2802-2815, (2007).
http://mbe.oxfordjournals.org/cgi/reprint/24/12/2802

Sequence-based analysis of pQBR103; a representative of a unique, transfer-proficient mega plasmid resident in the microbial community of sugar beet. A Tett, AJ Spiers, LC Crossman, D Ager, L Ciric, JM Dow, J Fry, D Harris, A Lilley, A Oliver, J Parkhill, MA Quail, PB Rainey, NJ Saunders, K Seeger, LAS Snyder, R Squares, CM Thomas, SL Turner, X-X Zhang, D Field & MJ Bailey. ISME Journal 1: 331-340, (2007).
http://www.nature.com/ismej/journal/v1/n4/full/ismej200747a.html

Neisseria: a post-genomic view. LAS Snyder, P Jordan & NJ Saunders. Pathogenomics, ASM Press, 2007.
http://estore.asm.org/viewItemDetails.asp?ItemID=700

Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18. SD Bentley, GS Vernikos, LAS Snyder, C Churcher, C Arrowsmith, T Chillingworth, A Cronin, P Davis, N Holroyd, K Jagels, M Maddison, S Moule, E Rabbinowitsch, S Sharp, L Unwin, S Whitehead, MA Quail, M Achtman, B Barrell, NJ Saunders & J Parkhill. PLoS Genetics 3: e23, (2007).
http://genetics.plosjournals.org/archive/1553-7404/3/2/pdf/10.1371_journal.pgen.0030023-S.pdf

The small FNR regulon of Neisseria gonorrhoeae: comparison with the larger E. coli FNR regulon and interaction with the NarQ-NarP regulon. R Whitehead, TW Overton, L Snyder, H Smith, J Cole & N Saunders. BMC Genomics 8: article 35, (2007).
http://www.biomedcentral.com/content/pdf/1471-2164-8-35.pdf

Comparative Genomics: The nature of CGH analysis and the use of probability scores and comparative methods in data interpretation. LAS Snyder, N Haan, G Snudden & NJ Saunders. Microarray Technology through Applications, Ed. F Falciani, Taylor & Francis, 2007.
http://www.routledge.com/books/Microarray-Technology-Through-Applications-isbn9780415378536

Coordinated regulation of the Neisseria gonorrhoeae truncated denitrification pathway by the nitric oxide-sensitive repressor, NsrR, and nitrite-insensitive NarQ-NarP. TW Overton, R Whitehead, Y Li, L Snyder, N Saunders, H Smith & J Cole. Journal of Biological Chemistry 281: 33115-33126, (2006).
http://www.jbc.org/cgi/reprint/281/44/33115

The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica, including those designated as 'virulence genes'. LAS Snyder & NJ Saunders. BMC Genomics 7: article 128, (2006).
http://jb.asm.org/cgi/reprint/188/13/4769

Ecf, an alternative sigma factor from Neisseria gonorrhoeae, controls expression of msrA/B, which encodes methionine sulfoxide reductase. IC Gunesekere, CM Kahler, CS Ryan, LAS Snyder, NJ Saunders, JI Rood & JK Davies. Journal of Bacteriology 188: 3463-3469, (2006).
http://jb.asm.org/cgi/reprint/188/10/3463

Complete and variant forms of the 'Gonococcal Genetic Island' in Neisseria meningitidis. LAS Snyder, Jarvis SA & NJ Saunders. Microbiology 151: 4005-4013, (2005).
http://mic.sgmjournals.org/cgi/reprint/151/12/4005

Comparative overview of the genomic and genetic differences between the pathogenic Neisseria strains and species. LAS Snyder, JK Davies CS Ryan & NJ Saunders. Plasmid 54: 191-219, (2005).
http://www.sciencedirect.com/science/journal/0147619X

The neisserial genomes: what they reveal about the diversity and behaviour of these species. Nigel J Saunders and Lori A. S. Snyder. The Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics, John Wiley & Sons, 2005.
http://eu.wiley.com/WileyCDA/WileyTitle/productCd-0470849746.html

Genetic islands of Streptococcus agalactiae strains NEM316 and 2603VR and their presence in other Group B Streptococcal strains. MA Herbert, CJB Beveridge, D McCormick, E Aten, N Jones, LAS Snyder & NJ Saunders. BMC Microbiology 5: article 31, (2005).
http://www.biomedcentral.com/1471-2180/5/31

Strain-specific differences in Neisseria gonorrhoeae associated with the phase variable gene repertoire. P Jordan, LAS Snyder & NJ Saunders. BMC Microbiology 5: article 21, (2005).
http://www.biomedcentral.com/1471-2180/5/21

Microarray genomotyping of key experimental strains of Neisseria gonorrhoeae reveals gene complement diversity and five new neisserial genes associated with Minimal Mobile Elements. LAS Snyder, JK Davies & NJ Saunders. BMC Genomics 5: article 23, (2004).
http://www.biomedcentral.com/1471-2164/5/23

Diversity in coding tandem repeats in related Neisseria spp. P Jordan*, LAS Snyder* & NJ Saunders. BMC Microbiology 3:23, (2003). *These authors contributed equally.
http://www.biomedcentral.com/1471-2180/3/23

Adaptation by phase variation in pathogenic bacteria. LA Salaün, LAS Snyder & NJ Saunders. Advances in Applied Microbiology 52: 263-301, (2003).
http://www.sciencedirect.com/science/bookseries/00652164